Current Studies

Research Area	Study Title
A & E	REVIVE - Randomised comparison of the effectiveness of the Laryngeal Mask Airway Supreme, i-gel and current practice in the initial airway management of pre-hospital cardiac arrest.
A & E	EDIT - the impact of foundation doctors training: impact on workforce wellbeing and patient care plase II
Cardiology	Yorkshire Heart - Prospective validation of prognostic markers in patients with chronic heart failure.
Cardiology	HoldFAST - Ethnographic study of admission for heart failure
Dermatology	BADBIR - British Association of Dermatologists@ Biological Interventions Register
Diabetes	T Cell studies in Type 1 Diabetes
Diabetes	Dietary assessment for people with Type 2 diabetes - Development of a brief evidence-based tool to assess dietary intake and promote healthy dietary change for people with Type 2 diabetes
Diabetes	TrialNet - Natural History Study of the development of Type 1 Diabetes
Diabetes	DARE - Diabetes Alliance for Research in England
Diabetes	AdDIT - Adolescent Typle 1 Diabetes Cardio-Renal Protection Study
Diabetes	SWENDIC II - the South-West Newly-Diagnosed Diabetes Collection - 2.
Diabetes	EXTOD -Barriers and Benefits of regular exercise in patient with type 1 diabetes
Diabetes	ADDRESS 2 - An incident and high risk type 1 diabetes research cohort After Diagnosis Diabetes Research Support System2
Diabetes	CODIFI: Concordance in Diabetic Foot Infection
Gastroenterology	PBC Genetics study - Investigation of the genetic and molecular pathogenesis of primary biliary cirrhosis
Gastroenterology	STOPAH - Steriods Or Pentoxifylline for Alcoholic Hepatitis
Gastroenterology	Steroid resistance in Alcoholic hepatitis - Predicting clinical outcome & strategies for reducing mortality
Gastroenterology	ChOPIN - Chemoprevention Of Premalignant Intestinal Neoplasia Incorporating Inherited Predisposition of Neoplasia (IPOD) analysis of genomic DNA from AspECT and BOSS clinical trials.
General Studies	eTHoS - A pragmatic multicentre randomised controlled trial comparing stapled haemorrhoidepexy to tranditional excisional surgery for haemorrhoidal disease.
Haematology	FCLL - Genetic study of Chronic Lymphocytic leukaemia and Other Lymphoproliferative Disorders
Haematology	PACIFICO - Purine-Alkylator Combination In Follicular lymphoma Immuno-Chemotherapy for Older patients: a phase III comparision of firstline R-CVP vs. R-FC lite
Haematology	NSHLG - Lymphoma Genetics (Hodgkin's)
Haematology	RIAltO - A Randomised Investigation of Alternative Ofatumumab- containing regimens in less fit patients with CLL
Occupational Therapy	PD Gen - Parkinson's Disease DNA Bank
Oncology	NSCCG - National study of colorectal cancer genetics
Oncology	MALCS - A population based case-control study of mesothelioma and lung cancer in relation to occupation among british men and women under the age of 60
Oncology	SUPREMO - a phase III randomised trial to assess the role of adjuvant chest wall irradiation in intermediate risk bresat cancer after mastectomy.
Oncology	SCOT - Short course oncology therapy - A study of adjuvant chemotherapy in colorectal cancer
Oncology	BETH - A multicentered Phase III randomised trial of adjuvant therapy for patients with HER2 - positive, node-postive or high risk node-nagetive breast cancer comparing chemotherapy plus Transtuzumab with chemotherapy plus Transtuzumab plus Bevacizumab
Oncology	OE05 - A randomised controlled trial comparing standard chemotherapy follwed by resection vs. ECX chemotherapy followed by resection in patients withs resectable adenocarcinoma of the oesophagus
Oncology	REAL 3 - Randomised Trial of the efficacy of epirubicin, oxaliplatin and capecitabine (EOX) with or without Pantitumumab for Advanced or Locally Advanced Oesophago-gastric Cancer
Oncology	UKGPCS - Genetic Prostate Cancer Study: Epidemiology and Molecular Genetic Studies
Oncology	LaMB - A phase III randomised 2 arm comparison of maintenance lapatinib vs. placebo after first line chemotherapy in patients with Her1 and/or Her2 over expressing localy advanced or metastatic bladder cancer
Oncology	POETIC - Trial of Perioperative Endocrine Theraphy - Individualising Care.
Oncology	SATIVEX - SPRAY III - A double blind, randomised placebo-controlled, parallel group study of Sativex oromucosal spray as adjunctive therapy in relieving uncontrolled persistent chronic pain in patients with advancecd cancer, who experience inadequate analgesia during optimised chronic opioid therapy
Oncology	SATIVEX - SPRAY IIi F/U - A multicentre, non-comparative, follow-on study to asess the long term safety of Sativex oromucosal spray (SativexA; Naboximols) therapy in patients with cancer related pain
Oncology	RADICALS - Radiotherapy and Androgen Deprivation In Combination After local Surgery. A Randomised controlled Trialfor Prostate Cancer
Oncology	Chemoradiation - Oesophageal squamous cell cancer: chemoradiotherapy versus chemotherapy and surgery - a feasibility study
Oncology	PRESENT - An investigation of genetic factors involved in predisposition to and pathogenesis of serrated polyps and cancers of the large bowel: The Predisposition to Serrated neoplasia and Tumours (PRESENT) study
Oncology	IMPORT HIGH - Randomised Trial testing Dose Escalated Intensity Modulated Radiotherapy for Women treated by Breast Conservation Surgery and Appropriate Systemic Therapy for Early Breast Cancer
Oncology	FOxTROT - Fluoropyrimidine, oxaliplatin and targeted receptor pre-operative therapy: a controlled trial in high-risk operable colon cancer
Oncology	MERCURY II - The Magnetic Resonance Imaging and Rectal Cancer European Equivalence Study - Low Rectal Cancer Study
Oncology	STO3 - A randomised Phase II/III trial of Peri-operative Chemotherapy with or without Bevacizumab in Operable Adenocarcinoma of the Stomach and Gastro-oesopahageal Junction
Oncology	STAMPEDE - Systemic therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug efficacy
Oncology	FAST-Forward - Randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer.
Oncology	Depression and Anxiety in Prostate Cancer
Oncology	SMART - Surgical and large bore pleural procedures in Malignant Pleural Mesothelioma And Radiotherapy Trial.
Oncology	ICON 8 - An international phases III randomised trial of dose-fractionated chemotherapy compared to standard three-weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian, fallopian tube or primary peritoneal cancer.
Oncology	STARRCAT - Surgical Timing After Radiotherapy for Rectal Cancer: Analysis of Technique.
Oncology	Brightlight - TYA Cancer Cohort - Do specialist cancer services for teenagers and young adults add value?
Oncology	BIL QoL - Validation of a disease-specific questionnaire module in assessing the quality of life of patients with cholangiocarcinoma and gallbladder cancer.
Oncology	DESKTOP III - A randomised culticentre study to compare the efficacy of additonal tumour debulking surgery vs. Chemotherapy alone for recurrent platinum-sensitive ovarian cancer.
Oncology	TIMELY - Trial of BIBW 2992 In suspected Mutant EGFR Lung cancer patients unfit for chemotherapy - non small cell lung cancer and suspected EGFR mutation considered unfit for chemo.
Oncology	Epidemiological aspects of the NHS Bowel Cancer Screening programme: False Positives Research Study
Oncology	Melanoma Lifestyle - A Genetic Epidemiological Study of Melanoma to Investigate the Protective Role of Vitamin D for relapse
Oncology	EPOC B - An exploratory study to investigate the optimal scheduling of chemotherapy in patients with operable colorectal liver metastases
Oncology	QUARTZ - A phase III multi-centre randomised controlled trial to assess whether optimal supportive care alone (including dexamethasone) is as effective as optimal supportive care (including dexamethasone) plus whole brain radiotherapy in the treatment of patients with inoperable brain metastases from non-small cell lung cancer
Oncology	SORCE- A Phase lll randomised double-blind study comparing Sorafenib with Placebo in patients with resected primary cell carcinoma at high or intermediate risk of relapse
Oncology	PATCH - Prostate Adenocarcinoma: TransCutaneous Hormones. A randomised controlled trial of trasanscutaneous oestrogen patches vs. LHRH analogues in protstate cancer
Rheumatology	1 - ERAN - Prospective obvservational study of the secondary care management of patients with early rheumatoid arthritis in the UK
Rheumatology	BRAGGSS - Investigation of genes influencing response to therapy with Etancercept in patients with rheumatoid and related arthropathies
Rheumatology	DELAY - Help seeking behaviour in patients with new onset rheumatoid arthritis: understanding the reasons for delay in GP consultation andf strategies to reduce this delay.
Rheumatology	Exploring the existence of a subset of rheumatoid arthritis defined by a characteristic cytokine profile.

Current Studies

Research Area

Study Title